Adrafinil was the precursor in the development of Modatab. It was used as a stimulant drug to treat narcolepsy and other sleep disorders. Lafon Laboratories in France developed Adrafinil in the late 1970s. It did not lead to anxiety and addictive behaviour as other stimulant drug. However, Adrafinil took a long to work after being ingested. This was because it too a long time to get metabolize within the body.
Further research lead to Modatab, which was developed by a neurophysiologist and emeritus experimental medicine professor Michel Jouvet at Lafon Laboratories. Modatab is a primary metabolite of Adrafinil. It has the same effects as Adranifil and widely used than its precursor.
The U.S. Food and Drug Administration approved Modatab for treatment of narcolepsy in 1998. By 2003, it was approved for use of treatment of shift work sleep disorder as well as obstructive sleep apnea/hypopnea.
Armadofinil was approved by FDA in 2007 and sold as Nuvigil. It is an enantiomer of Modatab and is used for treatment of narcolepsy, shift work disorder as well as sleep apnea.
As Modatab has shown little or no side effects as well as non-dependency after long-term use, it has become the most sort after eugeroic. Apart from sleep disorders, it is also prescribed for people with attention deficit disorder, multiple sclerosis (MS), treatment-resistant depression, etc.
In some cases, it is also prescribed to patients suffering from chronic fatigue syndrome, multiple sclerosis, cerebral palsy, Parkinson’s disease, etc. Modatab is a wonder drug in true sense, and can be used to promote mental alertness and crystal clear thinking in people who need it the most.